The isolation technology production takes place inside isolators, which are in effect chambers of variable dimensions depending on the type of process to be carried out, which ensure the confinement of a series of operations guaranteeing a triple level of protection: 01 OPERATOR PROTECTION; 02 PRODUCT PROTECTION; 03 EXTERNAL ENVIRONMENT PROTECTION.
01 - The operator's protection from dangerous product contamination is guaranteed by the physical barrier represented by the isolator, by the negative air pressure regime towards the external environment as well as by the handling and transfer devices suitable to avoid any direct contact with the produced during different stages of the process.
02 - The protection of the product from contamination from the external environment is guaranteed by an absolute filtration system (Hepa) placed on the suction side. This device ensures that the external air comes into contact with the substance to be treated only after appropriate filtration, thus ensuring the control of airborne pollutants.
03 - The protection of the external environment is guaranteed by an additional absolute filtration system (Hepa) placed at the exhaust. This device ensures adequate treatment of the internal atmosphere before expulsion to protect the environment and also the operator.

Nuova Guseo isolators are offered in multiple configurations: single or multi-chamber, in active or passive version (with or without integrated ventilation system and relative control system).
The proposed systems can be interfaced with various process machines such as reactors, filter dryers, centrifuges, static ovens, etc., they can also integrate devices for kilolabs, weighing, dispensing, grinding and various other process activities.


The design and construction criteria of the isolators, in compliance with the reference standards, provide for: • a high degree of internal finishing in order to avoid the accumulation of treated substances while the control of the air flows minimizes the contact of the product with the internal surface processing chambers; all this in order to facilitate cleaning operations when changing the product • internal cleaning devices with relative draining bottom in which the contaminated liquid is conveyed • an ergonomic design for easy access to all internal surfaces and work areas in relation to the process performed - possibility of performing ergonomic test ( mock up test) • use of glove ports of variable shape and size and feasible in different materials, suitable for easy replacement of the gloves used while maintaining the integrity of the system, • use of gloves of different sizes and materials in relation to the operational needs, the characteristics of the washing solvents used and the product to be handled • use of high efficiency filters of different types (screwed, push-through, push-push, bag in bag out), which can be replaced in safe conditions for the operator. • prearrangement for the installation / integration of product transfer systems, process tools and waste material outlet (continuous liner, Rapid Transfer Port, split valve, etc.) • instrumentation and alarms appropriate according to operational and safety requirements • possible integration with automatic non-electric pressure regulation valve (PV) and control systems that can be implemented in various ways, from basic configurations to control the internal pressure regime and any interlocks, up to the most sophisticated solutions with PLC and GAMP 5 and CFR 21 compliant software.

An integral part of the Nuova Guseo production range is represented by glove box and isolators designed for particular applications, i.e. systems capable of maintaining inert atmosphere conditions for the processing of oxygen-sensitive products, realizations in materials / coatings suitable for the processing of acid products.

The isolators designed for weighing and dispensing can have the following configurations:
Configuration with product inlet pre-chamber and main processing chamber with independent ventilation and internal cascade pressures
Interlocked doors for product entry and transfer to the main chamber.
Front window bolted or hinged to the isolator frame
Supporting platform for weighing device
Integration of the weighing terminal on the isolator front or integrated in the operator panel of the control system
Cable glands for the wiring of the installed devices
Implementation with side continuous liner or Rapid Transfer Port for product and waste outlet
Support shelves for tools, containers


Washing and drying gun
Spray balls
Lighting lamp (s)

The insulators designed for sampling by paddle dryers can have the following configurations:
Single chamber configuration
Rear flange for connection to the dryer
Passive configuration with blanketing absolute filter
Configuration with angled gloved flanges
Visual on the upper side of the insulator
Side liner for product sample release
Cleaning by spray ball with shaped bottom for waste liquid drainage

For use in classified areas (with the presence of hazardous gas and / or dust mixtures) the equipment is manufactured in compliance with the 2014/34 EU Directive.